A multi-method study (microfluidics, genetics, in vivo imaging, modeling) shows the hook protein FlgE causally controls flagellar wrapping in Caballeronia insecticola, though evidence rests on rectangular channels and partial flagella visualization.
In silico Neural Cellular Automata runs (50 per condition) support aging as loss of morphogenetic goal-directedness, but the model is a minimal 16×16 system with no empirical validation and no public code.
RNAi knockdown of the nicotinic receptor subunit chrnal-E increased sleep in a cnidarian, but small samples (n=3), no rescue experiment, and unresolved stock identity keep the finding preprint-stage and tentative.
A high-quality narrative review argues sperm RNA, histone marks, and methylation instruct early embryo transcription, while flagging that the field's RNA-injection evidence may overstate effects due to supraphysiological doses.
Cryo-electron and genetic evidence shows a novel horizontal gene transfer route moving up to 1.1 Mbp of chromosome between clinical strains, though the conduit machinery and one-strand generality remain unestablished.
The first synapse-resolution whole-brain EM resource for a vertebrate, with same-specimen functional mapping, though conclusions come from one specimen and split errors dominate automated segmentation (~35:1 vs merge errors).
Animal and cell studies consistently show inflammatory and oxidative-stress signaling from plastic particles, but human causal data remain nearly absent, and industry funding of the exposure framework is a noted bias risk.
A conceptual BJPsych Open paper proposes vulnerability × engagement × sycophancy as a mechanism for chatbot-associated psychosis, explicitly labeled provisional because no original data test the mechanism.
A CDC-authored review synthesizes evidence that H5N1 and other influenza A viruses can reach mammalian gut tissue, while judging human risk from consuming contaminated raw milk as low but theoretically possible.
A GA + ML pipeline designed artificial proteorhodopsins absorbing at ~410 nm that enhanced C. necator growth under blue light, though proton pumping was inferred, never directly measured, and the work is unreviewed.
Equilibrium chemistry plausibly explains why cytosine and thymine are absent from meteorites while guanine, adenine, and uracil persist, but the model overproduces bases by 3–4 orders of magnitude and key assumptions remain untested.
A preprint maps AI model lineages onto population genetics with closed-form equilibria and CI-verified code, though small seed counts (3) and single-author AI-assisted production temper confidence.
Multi-omic evidence links low GPD1L expression to slowed human stem-cell developmental tempo, with CRISPRa shortening the segmentation clock by ~40–50 minutes, but only gain-of-function perturbations were tested and no in vivo genetic validation exists.
Across 50 observational studies, roughly four in five reported a positive association between social media use and adolescent depressive symptoms, while anxiety evidence was weaker and sometimes U-shaped; all evidence is observational with unvalidated exposure measures.
A 201-citation narrative review synthesizes helminth therapy, maggot debridement, and leech therapy with genuine molecular specificity, but the optimistic framing outruns a preclinical evidence base with no recombinant parasite-derived products in human trials.
Cross-species data (zebrafish, mice, C2C12 cells) support hypertrophy from orally administered globin digest, but there is no isonitrogenous protein control, small samples, corporate conflicts of interest, and an untested relay mechanism.
A VAE decoder rendered candidate preferred visual stimuli for 11 navigation regions from fMRI during virtual driving, but validation was qualitative, n=6 included two authors, and the code was not yet available.
A rare North Asian mitochondrial lineage (C4a2c1) in Kurumba genomes is dated to ~7 ka with no matching autosomal signal, but per-cluster sample sizes below 5 and no data availability statement weaken the inference.
Loneliness predicted cognitive decline and Alzheimer's risk in 823 older adults independent of objective isolation, yet was unrelated to neuropathology at autopsy, leaving the mechanism (reserve vs disease) unresolved.
An NEJM synthesis supports screening plus psychological therapies and lactation-compatible SSRIs, though the headline prevention claim (treating antenatal depression) rests on a single small observational study with an implausibly large effect.
Rutter's 2005 review concluded true autism prevalence likely rose from ~4 to 30–60 per 10,000 with most of the increase from ascertainment and diagnostic broadening, and no epidemiological support for MMR or thimerosal causation.
A Navigation Guide systematic review rates prenatal pyrethroid exposure as having "sufficient evidence" of neurodevelopmental harm at moderate quality, while noting interpretive asymmetry: two cohorts showed beneficial associations yet null results were read as residual confounding.
The LDDM framework achieved 79.5% top-1 docking success and micromolar wet-lab hits with crystallographically confirmed poses using as few as 57 tested compounds, though pose prediction is weakly validated and potencies remain hit-level.
In fed mice, intestinal fructose engages a distinct vagal population (Gpr65+/Rbp4+) that opposes satiety, but cell-type mapping used N=3 mice per group, males only, and the luminal fructose sensor remains unidentified.
A dual-color reporter in melanoma cells shows AP-1-dependent cis epigenetic memory of pre-drug gene-expression states during MAPK-inhibitor resistance, but evidence rests on one cell line, pharmacologic inhibition with off-target risk, and n=2–3 replicates.
A worm-only preprint links a common preservative to fat gain and shortened lifespan through SKN-1, but non-monotonic dose effects, missing datasets, and unreviewed status make the finding hypothesis-generating rather than established.
A provocative preprint proposes H2Aub degradation as an energy reserve during glucose starvation, but n=2 proteomics, a single cell line, no electron microscopy, and no isotope tracing leave the mechanism largely pharmacological corroboration.
Animal and in vitro evidence supports microplastic-driven dysbiosis and barrier damage, with particle size appearing to switch the harm mode, but no supplied record contained the full text and human causal data remain absent.
The astrocyte-secreted protease HTRA1 is oppositely regulated by stress in male versus female nucleus accumbens in both humans and mice, with bidirectional behavioral effects, though the work is an unreplicated preprint without effect sizes.
Fans of winning teams showed testosterone increases and losing-fan decreases in two naturalistic studies, but the samples were tiny (n=8, n=21) with no control for alcohol or diurnal timing.
A registered meta-analysis of 23 longitudinal cohorts (181,006 participants) found ~29% higher CHD and ~32% higher stroke risk with poor social relationships, though funnel asymmetry suggests the true pooled effect may sit nearer ~18–19%.
A stop-gain FANCI variant appeared in 3 of 101 elite athletes and 0 of 1,899 comparators, but the Bonferroni-adjusted p=0.069, absent carrier phenotyping, and no replication make the benefit claim exploratory at best.
Airway organoids from five mammalian species recapitulated known viral species-tropism for H1N1, SARS-CoV-2 pseudovirus, and OC43, though SARS-CoV-2 testing was pseudovirus-only and the biomarker claim rests on two virus-host pairs.
The first fully wireless, single-cell-resolution miniscope achieved working CA1 place-cell imaging across a large arena, with evidence that tether drag rather than head-mounted mass drives locomotor disruption, though behavioral data came from only 3 male mice treated as independent.
Godfray et al.'s highly cited Science review framed food security as requiring combined levers (yield gaps, waste, diet, equity), a stance later quantitatively confirmed by planetary-boundary modeling, though the paper itself is narrative with no recomputable data.
Of 3,570 screened compounds, only fenretinide showed brain penetration and survival benefit in orthotopic diffuse midline glioma models (median 53→58 days), while negative brain-PK results for SAHA, ivermectin, and lanatoside C preempt likely clinical failures.
In the world's longest-running tropical drought experiment, drought-primed trees recovered transpiration fully within 143 days versus 77.5% recovery in controls, but the finding comes from a single plot pair and resilience bootstraps were robust in only 71.5% of resamples.
Engineered crack-opening seedpods held seeds 2–3°C warmer and drier than soil and accelerated early seedling emergence, but the field test was irrigated at a single site and the timing-versus-microclimate mechanism was not factorially isolated.
Nicotinamide riboside protected Alport-model mice by restoring the NAD+/PGC-1α/PPARα/fatty-acid-oxidation axis in proximal tubules, replicated in both sexes with deposited data, though causal proof of NAD+ depletion and human data are still missing.
A randomized placebo-controlled fMRI study (n=18/group) found psilocybin increased topological distances between meditation-state brain graphs, correlated with derealization and insightfulness, but with small samples, borderline p-values, and no replication cohort.
A dual-functionalized nanoparticle delivered CRISPR-Cas9 achieving ~40% β-catenin knockout and enhanced CD8+ T-cell killing in vitro, but the evidence is entirely cell-culture-based with confounded T-cell readouts and no off-target sequencing.
CRISPR knockouts show ZP-domain proteins Trinity and Miniature structurally pattern Heliconius sara scale nanostructures, with min loss producing unprecedented cylindrical scales, though individual-level sample sizes were only 2–3 per group without rescue.
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