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Updated June 07, 2026

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Raw biology, organized by mechanism: signal, state change, and outcome, all grounded in source data.

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Featured biology

Brain, metabolism, development, symbiosis, and ecology, each linked to a raw-data story.

NPSLE and NMDA receptor cross-reactivity

Neuroimmunology

Antibodies that can switch from signal to injury

DWEYS-reactive lupus IgG can amplify NMDA signaling at low levels and drive mitochondrial toxicity at higher ones, making dose a gate between function and damage.

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Astrocyte TNFR1 and memory rescue in Alzheimer’s mice

Aging brain

A fast circuit reset in Alzheimer’s mice

Deleting astrocyte TNFR1 restores memory in aged AD mice without clearing plaques, suggesting a rapid network reset rather than slow disease remodeling.

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Coenzyme A redox sensing in malic enzyme 2

Redox metabolism

Coenzyme A becomes a redox sensor

Oxidized coenzyme A binds malic enzyme 2 and re-tunes NADPH output under stress, turning a carrier cofactor into a sensor of oxidative state.

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Stem cells

Mandibular stem cells with tooth-building power

FOXP4-marked mandibular stem cells can build bone and tooth tissue, but primary cilia keep the regenerative program on track.

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Symbiosis

A symbiont that rewrites host time

Photosynthetic endosymbionts reorganize a ciliate’s daily transcriptome, and paraquat pulls the schedule back toward an aposymbiotic pattern.

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Predation risk and breeding dispersion in frogs

Behavioural ecology

Predation can flip breeding from spread-out to clustered

Crow risk can reverse how density shapes nest spacing, showing that danger can rewrite the social geometry of a population.

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Antibodies that can switch from signal to injury

A fast circuit reset in Alzheimer’s mice

Coenzyme A becomes a redox sensor

Mandibular stem cells with tooth-building power

A symbiont that rewrites host time

Predation can flip breeding from spread-out to clustered

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