Claims with supporting evidence, scope, and stated limitations. Also available via MCP for Claude, Cursor, and compatible tools.
Updated October 28, 2026
High-LET radiation biology findings from 10.1038/s41598-024-51756-7 appear robust within their limited model scope, but the lead author's declared cofounder/shareholder stake in Genegoggle shifts the burden toward proving commercial and scientific independence in data interpretation.
Commercial detectors flagged a pre-LLM 1987 constitution as 98.5% AI-generated and over-flag non-native English writers, indicating false positives track textual register rather than actual AI exposure — so high-formality genres remain structurally unprotectable (evidence).
One of the first high-profile syntheses of the microbiota–gut–brain axis, catalyzing a field, though its causal claims rest largely on small rodent studies and remain correlational (paper review); a key open question is whether microbiota interventions only work within a developmental critical window.
A Circulation study linked these species' depletion in coronary artery disease patients to atheroprotection in mice via reduced gut LPS, with the heat-killed control implying live microbial competition rather than immune stimulation — but human causality remains correlational and findings are population-specific (paper review).
An engineered Snodgrassella alvi symbiont expressing dsRNA reduced parasite replication and improved bee survival in a high-novelty PNAS study, though small sub-experiment sample sizes limit rigor (author review).
De Filippo's landmark comparison found ~4-fold higher faecal butyrate and Prevotella enrichment in rural African children, but the pilot-scale design (n≈15/group) cannot establish causation or protective effect (paper review).
Single-cell TCR sequencing identified EBNA1-primed CD4+ T cells cross-reactive with the MS autoantigen ANO2, extending antibody-only evidence into the T cell compartment — with caveats of small single-cell samples, natalizumab confounding, and undisclosed raw data (paper review).
A CDC mBio minireview concludes ingestion of contaminated material (e.g., raw milk) can theoretically establish H5N1 infection, but human risk from consumption is judged low and direct evidence of replicating virus in human GI tissue is lacking (paper review).
Promising in vitro activity against M. tuberculosis via inferred Gyrase A targeting, with the mechanism still supported only by modeling rather than direct enzyme inhibition assays (author review).
A rigorously designed multicenter protocol using TMLE addresses the intravesical-therapy vs. cystectomy quality-of-life trade-off, but results are not yet reported — only the protocol exists (author review).
Dipeptide repeat proteins inhibit GEM body formation in iPSC-derived ALS neurons, implicating RNA metabolism dysregulation alongside protein misfolding — pending in vivo validation (author review).
In a UK cohort (N=8,913), social media use at age 11 showed no direct link to age-17 distress; harm operated through indirect paths (distrust, late sleep, negative body image), with the distrust pathway significant only in females (paper review).
A systematic review of 50 studies finds ~4 in 5 reporting positive depression associations while anxiety evidence is weaker and sometimes U-shaped — entirely observational and narrative-only, with no per-study effect tables provided (paper review).
Loneliness predicted cognitive decline and Alzheimer's risk over 65 months in 823 adults, yet was unrelated to autopsy neuropathology — suggesting effects on cognitive reserve rather than disease progression itself (paper review).
A BJPsych Open conceptual paper proposes a plausible vulnerability × sycophancy × hallucination loop for chatbot-associated psychosis, but rests on no original data and the true attributable fraction is genuinely unknown given co-occurring confounders (paper review).
A preprint rendered "preferred visual experiences" for 11 navigation regions from fMRI, generating a testable TPJ vehicle-tuning hypothesis — but validation is largely qualitative, with n=6 including two author-participants (paper review).
A prospective replication found high-activity MAOA buffered abused white individuals from later violent behavior but showed no protective effect in non-white participants — an ancestry-dependent null anticipating modern polygenic-score portability problems (paper review).
Rutter concluded true ASD incidence likely lies at 30–60 per 10,000 versus the original 4 per 10,000, with most of the rise explained by broadened diagnostics and ascertainment and no epidemiological support for MMR or thimerosal causation (paper review).
From available evidence, only one high-quality MMR–ASD study exists (UK case-control, OR 0.86, 95% CI 0.68–1.09), so a pooled estimate cannot be honestly computed without inflating the evidence base (analysis).
Single-cell sequencing estimates ~13.7 somatic L1 insertions per human hippocampal neuron (raw mean 30.4), with a ~4-fold spread between artifact-inclusive and corrected estimates making the true burden a methodology question (paper review).
A high-quality review synthesizes how sperm histone marks, DNA methylation, and small RNAs instruct early embryos, but flags that the field's strongest RNA-injection evidence may overestimate effects due to supraphysiological doses (paper review).
A preprint reports cryptic Kota/Kurumba substructure and a rare North Asian mtDNA lineage (C4a2c1, ~7 ka) with no autosomal Northeast Asian signal — illustrating how a single surviving mtDNA lineage can persist ~200 generations and mislead ancestry claims (paper review).
An inducible mtDNA-depletion mouse model showed wrinkles and hair loss fully reversed upon transgene shutoff, implying some aging phenotypes are plastic mitochondrial states rather than accumulated damage — though the key source is a non-peer-reviewed conference abstract with small cohorts (paper review).
A Neural Cellular Automata model argues aging emerges from loss of morphogenetic goal pursuit rather than damage per se — conceptually bold and testable in silico, but with no empirical validation and no public code (paper review).
Adult rat exercise engaged resident c-kit+ progenitors driving new myocyte and capillary formation, challenging the pure-hypertrophy dogma — but genetic lineage tracing to confirm progenitor origin is still missing (paper review).
Abrupt soft/stiff boundaries in 3D GelMA hydrogels drove perpendicular fibroblast alignment and localized myofibroblast differentiation via mechanical cues alone, with conclusions limited to single-cell-model 2D-projected in vitro contexts (author review).
Cell-envelope conduits enabled recombination of chromosomal tracts up to 1.1 Mbp (~27% of the genome) between clinical strains — a genuinely novel HGT mechanism demonstrated in only one strain pair with the conduit machinery still unidentified (paper review).
Caballeronia insecticola traverses micrometer-scale host constrictions via flagellar wrapping, with hook (FlgE) stiffness causally controlling the behavior — a multi-modal microfluidics/genetics study whose primary evidence is insect-symbiont-specific (paper review).
First microscopy of Hodarchaeales cells showed unusually large (~3 µm) morphotypes near the prokaryote–eukaryote boundary, but the claim rests on FISH signal geometry alone (n=40 cells, one site) and demands ultrastructural arbitration (paper review).
Pantoea dispersa metabolizes benzoxazinoids via plasmid-borne genes and is vertically transmitted through fall armyworm eggs, with detoxification concentrated in the Malpighian tubule rather than the midgut — though strain specificity limits generality (paper review).
Equilibrium chemistry in planetesimals explains cytosine's absence (rapid deamination) and thymine's oxidation in meteorites while adenine, guanine, and uracil persist — a testable retrodiction for pristine Ryugu/Bennu samples, though the model overproduces nucleobases by 3–4 orders of magnitude (paper review).
Across mammals and landfills, methanogen composition — not total abundance — predicts methane output, so Mars-analog microcosm experiments should prioritize taxonomic compensation as the decisive readout (experiment design).
A GA + ML pipeline designed rhodopsins absorbing at ~410 nm that enhanced bacterial growth under blue light, though proton pumping was never directly measured and the work is preprint-stage (paper review).
Thirty years of consistent rodent wound-healing data with plausible VEGF/ERK mechanisms, yet fewer than 30 humans ever studied, zero RCTs, and demand met entirely by unregulated grey-market supply (evidence review).
A proposed three-arm RCT would test psilocybin under propofol anesthesia to determine whether conscious psychedelic experience is causally necessary for antidepressant effects — novel and conceptually rigorous but underpowered (n=9) and confounded by integration therapy (paper review).
Both the original in vitro study and its critique share the same flaw — extrapolating across the in vitro/in vivo boundary without measuring hepatocyte nanoparticle concentration or clearance kinetics (paper review).
A preprint implicates the SKN-1/Nrf2 pathway in sodium benzoate's obesogenic and lifespan-shortening effects, but non-monotonic dose responses and worm-assay confounds (osmolarity, food intake) keep the finding hypothesis-generating at best (paper review).
Stage-specific globin peptides promoted hypertrophy across zebrafish, mice, and C2C12 cells, but MyHC protein rose without mRNA change — suggesting translational rather than transcriptional action, with corporate COIs and missing raw data limiting quality (paper review).
A narrative review synthesizes helminth, maggot, and leech therapy with genuine molecular specificity, but relies almost entirely on preclinical data — and zero recombinant parasite-derived immunomodulators have reached human trials in over a decade (paper review).
~150 min/week of activity prevents weight gain while 250–300 min/week plus resistance training is needed for clinically significant loss and organ-level repair — minimum and optimal doses differ roughly twofold (evidence summary).
The bimodal 232–243 peptide population shift offers a ratiometric, drift-resistant readout for weak magnetic-field effects — best exploited via interleaved field-on/field-off sessions with the E505D mutant as artifact envelope control (experiment design).
Establishing whether systemic B/A ratio shifts precede or follow intrarenal changes requires Granger-style time-series analysis, since simultaneous co-variation confounds temporal causality (analysis plan).
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