Th1 immune programming

Evidence supports Th1 as a context-dependent, IFN-γ-centered program that can improve control of some intracellular microbes but also accompany tissue inflammation when excessive or misdirected.

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CX3CR1 in thymic macrophage efferocytosis

The review offers a plausible, hypothesis-generating model, but direct thymic causal evidence that CX3CR1 controls efferocytosis through calcium signaling is absent and conclusions remain context-dependent.

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