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Create Tables — Scientific Claims & Evidence

Updated October 05, 2026

Four claims on hydrogen bonding and evidence table requests. Each entry states the evidence-backed finding with its scope and limitations.

Amino acids forming strong intra-chain hydrogen bonds — donor/acceptor side chains and backbone geometry

Claim: Ionizable and polar side chains (Asp, Glu, Lys, Arg, His, Asn, Gln, Ser, Thr, Tyr, Trp) form the strongest intra-polypeptide hydrogen bonds, but strength depends mostly on position and burial rather than residue identity. Scope: structural survey of 44 protein structures; limitation: static crystal structures, not dynamic strength measurements.

Key numbers: 69% of intramolecular ionizable-side-chain interactions are hydrogen bonds, often to main-chain NH/CO; 78% involve buried atoms. Helix N-caps favor Asp/Glu, C-caps favor Lys/Arg.

Potential experiments

PCOS metabolite change ledger (carbohydrate, lipid, protein) attributed to Murri et al. 2013

Claim: A faithful carbohydrate/lipid/protein metabolite ledger cannot be built from Murri et al. 2013 because the source was not among the supplied evidence records. Substitute: quantified serum metabolite shifts in PCOS stratified by environment; limitation: values for the requested paper would be fabricated, so none were provided.

MRSA phenotypes for SCCmec XI / mecA(LGA251) from German EID study

Claim: Kriegeskorte et al. 2012 report a multiplex PCR assay validated on 185 isolates (127 mecA(LGA251)-positive) with 100% sensitivity and specificity distinguishing conventional mecA from the LGA251 homologue, identifying 12 new mecA(LGA251) MRSA cases in routine surveillance. Scope: Danish surveillance isolates; limitation: performance figures depend on the validated isolate panel.

Smartphone prenatal education — study characteristics, control groups, follow-up duration

Claim: No table of study characteristics, control groups, or follow-up durations can be produced because none of the supplied evidence records describe a smartphone-based prenatal education study. Available records instead cover: prenatal epigenetics and mental health, and rare autosomal trisomies; limitation: an empty evidence set, not negative findings.

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