BGPT: Physiology

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Evidence layer · Updated November 06, 2026

Apical Transporters for Neutral Amino Acids: Physiology and Pathophysiology

A 2008 review by Bröer connects newly cloned apical neutral amino acid transporters (SLC6 family, including B⁰AT1) to classical epithelial physiology and inherited aminoacidurias such as Hartnup disorder, iminoglycinuria, cystinuria, and lysinuric protein intolerance — though many assignments rest on single-species vesicle and oocyte data rather than direct in vivo confirmation.

Review · 2008 Kidney & intestine SLC6 transporters

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Key Insight

Human genetics outpaced biochemistry: mapping the Hartnup disease locus — not a physiological hypothesis — delivered the gene for system B⁰, making rare aminoacidurias useful reverse-genetics entry points into epithelial physiology.

Interpretation drawn implicitly from the review; the authors do not state it explicitly.

Evidence Scores

Scientific quality80%

Generality80%

Usefulness80%

Reproducibility60%

Novelty70%

Scores are BGPT editorial assessments; reproducibility is limited because claims trace to oocyte and vesicle experiments with variable documentation.

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