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     Long Analysis Plan


    Premise Check: Murri et al. 2013 Not Available

    The requested source, Murri et al. 2013 (a metabolomics study in PCOS comparing metabolic profiles), is not among the supplied evidence records. I cannot construct a faithful carbohydrate/lipid/protein metabolite change ledger from that paper without fabricating values. Instead, below is the closest sourced ledger available: quantified serum metabolite shifts in PCOS stratified by environment (urban vs rural), which does include lipid-class and carbohydrate/nucleotide-class metabolites.

    Sourced PCOS Metabolite Change Ledger (LC-MS/MS serum metabolomics, n=30 women; 16 urban, 14 rural, Rotterdam 2003 criteria)

    Values are log2 fold-changes as extracted from the study; no metabolite class assignments or protein-metabolite values were reported, so the carb/lipid/protein tri-partition requested cannot be fully populated.

    MetaboliteGrouplog2 Fold-ChangeDirectionInterpretable Class
    Xanthosine 5-triphosphateRural-PCOS3.1518UpNucleotide
    Cer(d18:1/22:0)Rural-PCOS2.2781UpLipid (ceramide)
    2-MethyloctacosaneRural-PCOS2.2495UpLipid-like hydrocarbon
    PalmitoneRural-PCOS2.2447UpLipid-related
    HemeRural-PCOS1.3325UpPorphyrin
    3-hydroxyicosanoic AcidRural-PCOS-1.4556DownLipid (fatty acid)
    UDP-beta-L-arabino furanoseUrban-PCOS-2.7718DownCarbohydrate/nucleotide-sugar

    The study reports that rural participants showed higher lipid-related metabolites while urban participants showed changes in carbohydrate and nucleotide metabolism, and the authors flag small sample size and unquantified lifestyle confounders (diet, physical activity) as key limitations .

    What is missing to answer the original request: the full-text quantitative metabolite tables of Murri et al. 2013. Supplying that paper would allow a proper carb/lipid/protein ledger to be built.



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    Updated: September 28, 2026



     Analysis Wizard



    Structuring the extracted urban-vs-rural PCOS metabolite fold-change data into a categorized, sortable metabolite ledger and visualizing directional shifts by class.



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    Create Tables: PCOS Metabolite Change Ledger (carb/lipid/protein) from Murri et al. 2013 Science Art

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