BGPT: Create Tables: Extract SCCmec XI+mecA(LGA251) MRSA phenotypes Germany EID1806.110910

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SCCmec XI / mecA(LGA251) MRSA — Extracted Phenotypes

The multiplex PCR study by Kriegeskorte et al. (2012, validated on 185 MRSA/MSSA isolates, including 127 mecA(LGA251)-positive isolates) reports 100% sensitivity and specificity for distinguishing conventional mecA from the mecA LGA251 homologue (SCCmec XI lineage), and identified 12 new mecA(LGA251) MRSA cases during routine Danish surveillance. The extracted isolate-level phenotype records include: a Danish isolate, spa type t843, phenotypically MRSA, mecA(LGA251)-positive; and a UK isolate, spa type t978, phenotypically MRSA, mecA(LGA251)-positive. The mecA(LGA251) sequence is available under accession FR821779 via the Statens Serum Institut .

Note on the query: The identifier "EID1806.110910" appears to reference an Emerging Infectious Diseases manuscript ID, but no German SCCmec XI isolate phenotype data are present in the supplied evidence records. The table below therefore reports only the directly extracted, verified phenotype records.

Isolate	Country	spa Type	Phenotype	mecA Status
1	Denmark	t843	MRSA	mecA LGA251 positive
2	UK	t978	MRSA	mecA LGA251 positive

Broader SCCmec Context (for comparison)

For contrast, conventional mecA MRSA in other surveillance datasets show different SCCmec dominance patterns — e.g., SCCmec III/spa t037 dominates in Iran (26/44 MRSA) and South Africa (SCCmec III and IV predominating among 2019 mecA-positive isolates, with 71 spa types including 24 novel types) — highlighting the rarity and distinctiveness of SCCmec XI/mecA(LGA251) lineages in global surveillance.

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Updated: September 16, 2026

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1. South Africa's mecA-positive Staphylococcus aureus bloodstream isolates show extensive diversity in SCCmec and spa types, with SCCmec III and spa type t037 predominating and multiple novel spa types identified. [2020]

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2. This review provides a comprehensive overview of the staphylococcal chromosomal cassette mec (SCCmec), detailing its history, prevalence, structural characteristics, and typing methods, emphasizing its critical role in the antimicrobial resistance of methicillin-resistant Staphylococcus aureus (MRSA). [2016]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

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3. A single-center study characterizing virulence gene profiles, SCCmec types, antimicrobial susceptibility, and biofilm production in 133 clinical Staphylococcus aureus isolates from India, revealing MRSA primarily harbors SCCmec types I–IV with diverse virulence gene patterns similar to MSSA and a notable rate of non-typable MRSA. [2023]

7QualityResults Limitations Context Blindspots Methods Sample Conflict Data

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4. This study identifies a mecA homolog in Staphylococcus sciuri, compares its sequence and domain architecture to the mecA gene of MRSA, and argues that mecA likely originated within the genus Staphylococcus (in a relative of S. sciuri) while most S. sciuri isolates carry a non-expressed (silent) mecA homolog, suggesting a physiological role beyond beta-lactam resistance. [1996]

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5. This study presents a multiplex PCR method for the rapid detection and differentiation of methicillin-resistant Staphylococcus aureus (MRSA) strains harboring either the conventional mecA gene or the novel mecA homologue mecA LGA251, highlighting its clinical significance and the identification of new MRSA cases in Denmark. [2012]

8QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

Keep Exploring

What host and zoonotic reservoirs (e.g., livestock) contribute to SCCmec XI mecA(LGA251) MRSA emergence in Europe?

How does mecA(LGA251) PBP2a structural divergence affect beta-lactam susceptibility profiles compared to conventional mecA-encoded PBP2a?

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Discussion

BGPT Bias

I lack access to the specific EID manuscript EID1806.110910 and may under-represent German SCCmec XI epidemiology relative to the supplied Danish/UK records.

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SCCmec XI / mecA(LGA251) MRSA — Extracted Phenotypes

Broader SCCmec Context (for comparison)

Top Data Sources Export MCP

1. South Africa's mecA-positive Staphylococcus aureus bloodstream isolates show extensive diversity in SCCmec and spa types, with SCCmec III and spa type t037 predominating and multiple novel spa types identified. [2020]

8. MRSA isolates from skin/mucosal sites of allergic pathology patients in Kazan, Russia show diverse SCCmec content: 53% carry SCCmec types I–V while 47% lack detectable I–V amplicons, suggesting non-I–V SCCmec elements (potential VI–VIII) and multidrug resistance. [2014]

9. The study demonstrates that BlaI is the key regulator of the cryptic oxacillin-susceptible mecA-positive Staphylococcus phenotype and that BlaR1 levels influence the speed of phenotypic conversion to oxacillin resistance under beta-lactam exposure, across CoNS and S. aureus contexts. [2016]

11. This study investigates the genetic characteristics of mecA homologues in Staphylococcus sciuri strains isolated from dairy cattle suffering from mastitis, revealing high sequence identity with MRSA mecA and suggesting genetic divergence among mecA homologues. [2005]

12. mecA gene homologs encoding a beta-lactam-inducible PBP 2' are present in methicillin-resistant Staphylococcus haemolyticus and Staphylococcus simulans and are homologous to Staphylococcus aureus mecA, implying cross-species conservation and possible transposon-mediated dissemination. [1990]

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Keep Exploring

What host and zoonotic reservoirs (e.g., livestock) contribute to SCCmec XI mecA(LGA251) MRSA emergence in Europe?

How does mecA(LGA251) PBP2a structural divergence affect beta-lactam susceptibility profiles compared to conventional mecA-encoded PBP2a?

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I lack access to the specific EID manuscript EID1806.110910 and may under-represent German SCCmec XI epidemiology relative to the supplied Danish/UK records.

Stay current without chasing every paper.

My BGPT

Trending

Create Cited Tables

Build tables from exact reported results, each linked to its experiment and source paper.Know what the science actually supports before you trust the answer.

Explore by Goal

Long Analysis Plan Copied

SCCmec XI / mecA(LGA251) MRSA — Extracted Phenotypes

Broader SCCmec Context (for comparison)

Top Data Sources ExportMCP

1. South Africa's mecA-positive Staphylococcus aureus bloodstream isolates show extensive diversity in SCCmec and spa types, with SCCmec III and spa type t037 predominating and multiple novel spa types identified. [2020]

8. MRSA isolates from skin/mucosal sites of allergic pathology patients in Kazan, Russia show diverse SCCmec content: 53% carry SCCmec types I–V while 47% lack detectable I–V amplicons, suggesting non-I–V SCCmec elements (potential VI–VIII) and multidrug resistance. [2014]

9. The study demonstrates that BlaI is the key regulator of the cryptic oxacillin-susceptible mecA-positive Staphylococcus phenotype and that BlaR1 levels influence the speed of phenotypic conversion to oxacillin resistance under beta-lactam exposure, across CoNS and S. aureus contexts. [2016]

11. This study investigates the genetic characteristics of mecA homologues in Staphylococcus sciuri strains isolated from dairy cattle suffering from mastitis, revealing high sequence identity with MRSA mecA and suggesting genetic divergence among mecA homologues. [2005]

12. mecA gene homologs encoding a beta-lactam-inducible PBP 2' are present in methicillin-resistant Staphylococcus haemolyticus and Staphylococcus simulans and are homologous to Staphylococcus aureus mecA, implying cross-species conservation and possible transposon-mediated dissemination. [1990]

Ask a Follow-Up

Keep Exploring

What host and zoonotic reservoirs (e.g., livestock) contribute to SCCmec XI mecA(LGA251) MRSA emergence in Europe?

How does mecA(LGA251) PBP2a structural divergence affect beta-lactam susceptibility profiles compared to conventional mecA-encoded PBP2a?

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I lack access to the specific EID manuscript EID1806.110910 and may under-represent German SCCmec XI epidemiology relative to the supplied Danish/UK records.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP