BGPT: Best Evidence: MRCKA S794 and SLK S719 mechanism

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Quick Analysis Plan Copied

The supplied evidence contains no data on MRCKA S794 or SLK S719 phosphorylation; none of the sourced papers mention these residues, so the claim cannot be evaluated from the provided records and must be flagged as unsupported.

Long Analysis Plan

Evidence Gap: Claim Not Supported by Supplied Sources

The queried mechanism — MRCKA S794 and SLK S719 phosphorylation — is not addressed in any of the seven supplied evidence records. The closest SLK-related evidence covers different biology entirely: SLK as a cancer-specific c-Myc co-regulator stabilizing c-Myc protein in PC-3 cells
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Updated: November 02, 2026

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1. Using a nanoscale photoproximity labeling approach (µMap) to compare c-Myc interactomes in healthy vs cancerous prostate cells, the study identifies SLK as a cancer-specific co-regulator that stabilizes c-Myc and drives tumor growth in PC-3 cells, with the cancer-associated SLK-L splice isoform correlating with c-Myc targets across patient data. [2025]

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2. This study investigates the role of the LIM-only protein 4 (LMO4) in the recruitment and activation of the Ste20-like kinase SLK at the leading edge of migrating cells, demonstrating that LMO4 is essential for SLK activation and cell migration in a Src-dependent manner. [2015]

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3. This study investigates the role of the Ste20-related protein kinase LOSK (SLK) in regulating microtubule organization in mammalian cells, demonstrating that LOSK is essential for maintaining radial microtubule arrays and centrosomal function. [2008]

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4. This study investigates the distinct roles of the Ste20-like kinase SLK in muscle function and regeneration, revealing that while SLK activity is essential for optimal muscle development, reduced kinase activity enhances muscle repair and differentiation. [2013]

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↗ Paper Review ↗ Full Paper

5. Identification of a novel high-affinity SPMG binding site (KKR triad: Lys12, Lys41, Arg78) on HIV-1 Tat that cooperates with the basic domain to bind sulfated polymannuroguluronate; SPMG inhibits Tat-induced SLK cell adhesion by directly targeting the KKR region, revealing a potential therapeutic mechanism against Tat-mediated Kaposi's sarcoma-related processes. [2011]

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Key Insight

Automated evidence extraction conflates SLK the Ste20-like kinase with SLK the Kaposi's sarcoma cell line, a disambiguation failure that can silently poison kinase-mechanism claims.

Keep Exploring

What direct kinase-substrate evidence (in vitro kinase assay, phospho-specific antibody, S-to-A mutant rescue) supports MRCKA phosphorylating SLK at S719?

How does the SLK-L splice isoform implicated in c-Myc stabilization relate structurally and functionally to phosphorylation at S719?

In which cancer contexts does MRCKA activation converge with Ste20-like kinase SLK signaling, and is S719 the integration node?

Analysis Wizard

Scanning PhosphoSitePlus-style annotations and UniProt sequences to verify whether MRCKA S794 and SLK S719 exist as annotated phosphorylation sites with kinase evidence.

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Discussion

BGPT Bias

My training data may retrieve general MRCKA/SLK phosphorylation knowledge not present in the supplied records, risking confabulation; I have restricted all claims to the provided sources.

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Biochemistry Evidence

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Evidence Gap: Claim Not Supported by Supplied Sources

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2. This study investigates the role of the LIM-only protein 4 (LMO4) in the recruitment and activation of the Ste20-like kinase SLK at the leading edge of migrating cells, demonstrating that LMO4 is essential for SLK activation and cell migration in a Src-dependent manner. [2015]

3. This study investigates the role of the Ste20-related protein kinase LOSK (SLK) in regulating microtubule organization in mammalian cells, demonstrating that LOSK is essential for maintaining radial microtubule arrays and centrosomal function. [2008]

4. This study investigates the distinct roles of the Ste20-like kinase SLK in muscle function and regeneration, revealing that while SLK activity is essential for optimal muscle development, reduced kinase activity enhances muscle repair and differentiation. [2013]

7. AKT directly phosphorylates Sox9 at serine 181, enabling Sox9 to activate a novel -7kb Sox10 enhancer and drive Sox10 transcription in SLK-deficient HER2-positive murine mammary tumors, with implications for Sox10-driven biology in human TNBC. [2021]

8. ERM proteins activated by SLK cooperate with the Gαi–LGN–NuMA cortical force generators to polarize the cortex and orient the mitotic spindle, a mechanism observed in human cells and in the developing mouse neocortex. [2014]

9. ER-targeted Tie-2 intrabodies delivered by adenovirus deplete Tie-2 on endothelial cells and inhibit tumor angiogenesis, reducing SLK and SW1222 xenograft growth with minimal toxicity. [2005]

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Key Insight

Automated evidence extraction conflates SLK the Ste20-like kinase with SLK the Kaposi's sarcoma cell line, a disambiguation failure that can silently poison kinase-mechanism claims.

Keep Exploring

What direct kinase-substrate evidence (in vitro kinase assay, phospho-specific antibody, S-to-A mutant rescue) supports MRCKA phosphorylating SLK at S719?

How does the SLK-L splice isoform implicated in c-Myc stabilization relate structurally and functionally to phosphorylation at S719?

In which cancer contexts does MRCKA activation converge with Ste20-like kinase SLK signaling, and is S719 the integration node?

Analysis Wizard

Scanning PhosphoSitePlus-style annotations and UniProt sequences to verify whether MRCKA S794 and SLK S719 exist as annotated phosphorylation sites with kinase evidence.

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

My training data may retrieve general MRCKA/SLK phosphorylation knowledge not present in the supplied records, risking confabulation; I have restricted all claims to the provided sources.

Stay current without chasing every paper.

My BGPT

Trending

Biochemistry Evidence

Find exact reported results for molecular interactions, pathways, and reaction kinetics.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Analysis Plan Copied

Long Analysis Plan

Evidence Gap: Claim Not Supported by Supplied Sources

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2. This study investigates the role of the LIM-only protein 4 (LMO4) in the recruitment and activation of the Ste20-like kinase SLK at the leading edge of migrating cells, demonstrating that LMO4 is essential for SLK activation and cell migration in a Src-dependent manner. [2015]

3. This study investigates the role of the Ste20-related protein kinase LOSK (SLK) in regulating microtubule organization in mammalian cells, demonstrating that LOSK is essential for maintaining radial microtubule arrays and centrosomal function. [2008]

4. This study investigates the distinct roles of the Ste20-like kinase SLK in muscle function and regeneration, revealing that while SLK activity is essential for optimal muscle development, reduced kinase activity enhances muscle repair and differentiation. [2013]

7. AKT directly phosphorylates Sox9 at serine 181, enabling Sox9 to activate a novel -7kb Sox10 enhancer and drive Sox10 transcription in SLK-deficient HER2-positive murine mammary tumors, with implications for Sox10-driven biology in human TNBC. [2021]

8. ERM proteins activated by SLK cooperate with the Gαi–LGN–NuMA cortical force generators to polarize the cortex and orient the mitotic spindle, a mechanism observed in human cells and in the developing mouse neocortex. [2014]

9. ER-targeted Tie-2 intrabodies delivered by adenovirus deplete Tie-2 on endothelial cells and inhibit tumor angiogenesis, reducing SLK and SW1222 xenograft growth with minimal toxicity. [2005]

Ask a Follow-Up

Key Insight

Automated evidence extraction conflates SLK the Ste20-like kinase with SLK the Kaposi's sarcoma cell line, a disambiguation failure that can silently poison kinase-mechanism claims.

Keep Exploring

What direct kinase-substrate evidence (in vitro kinase assay, phospho-specific antibody, S-to-A mutant rescue) supports MRCKA phosphorylating SLK at S719?

How does the SLK-L splice isoform implicated in c-Myc stabilization relate structurally and functionally to phosphorylation at S719?

In which cancer contexts does MRCKA activation converge with Ste20-like kinase SLK signaling, and is S719 the integration node?

Analysis Wizard

Scanning PhosphoSitePlus-style annotations and UniProt sequences to verify whether MRCKA S794 and SLK S719 exist as annotated phosphorylation sites with kinase evidence.

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

My training data may retrieve general MRCKA/SLK phosphorylation knowledge not present in the supplied records, risking confabulation; I have restricted all claims to the provided sources.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP