BGPT: Author Review: Aaron Schein (Uchicago statistics)

Explore by Goal

Quick Explanation Copied

No verifiable authorship evidence for Aaron Schein (UChicago Statistics) exists in the supplied records or OpenAlex; the retrieved EGFR-biology papers cannot be attributed to him, so a scientific strength assessment cannot be performed without fabricating data.

Long Explanation

Query cannot be validated. The OpenAlex author search for "Aaron Schein (Uchicago statistics)" returned zero matches, and none of the 16 supplied evidence records (EGFR trafficking, LDOC1, FUT8 fucosylation, CIN85, NSCLC TKI cohorts) list Aaron Schein as an author, nor do they show statistical/authorship provenance linking him to this work . Attributing these papers to a statistics-department researcher without documented authorship would be confabulation.

What is missing: an authoritative author identifier (OpenAlex/ORCID/Google Scholar profile), confirmed paper-authorship links, and citation metrics. Without these, no score, no bibliometric analysis, and no quality judgment can be honestly made. If you can supply his verified publication list, a rigorous author review can be built.

Feedback:

Updated: October 05, 2026

Top Data Sources Export MCP

1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

9QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

2. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

3. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

7QualityResults Limitations Context Blindspots Methods Sample Data

↗ Paper Review ↗ Full Paper

4. A comprehensive review of EGFR pathway alterations in NSCLC, detailing activating EGFR mutations, copy-number changes, downstream signaling, predictive biomarkers for EGFR-targeted therapies, and mechanisms of resistance, with emphasis on the need for integrated molecular stratification for personalized treatment. [2011]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

5. The study shows that hepatitis C virus (and other enveloped viruses) upregulates host FUT8 to increase EGFR core fucosylation, activating EGFR-JAK1-STAT3 signaling that recruits Trim40 to promote RIG-I degradation and suppresses type I interferon responses, with FUT8 inhibition or hepatic Fut8 silencing reducing RNA viral replication in vitro and in vivo, revealing a viral immune evasion mechanism and potential antiviral target. [2024]

9QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

Key Insight

Author-review queries fail silently when name-based author disambiguation fails; a single persistent identifier (ORCID) would have converted an unanswerable query into a fully traceable bibliometric analysis.

Keep Exploring

What persistent identifiers (ORCID, OpenAlex ID) exist for Aaron Schein affiliated with the University of Chicago Statistics department, and what is his verified publication record?

How do citation-disambiguation systems like OpenAlex handle common name collisions between statisticians and biomedical co-authors?

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I may be biased toward refusing attribution when identity evidence is ambiguous, erring on the side of under-attribution rather than plausible inference.

Stay current without chasing every paper.

Know what changed, what holds up, and what remains uncertain. Every Friday. No ads.

Check Claims Before You Publish

See how your reported results read as versioned evidence records — linked to experiments and limitations.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Explanation Copied

Long Explanation

Top Data Sources Export MCP

1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

2. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

3. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

6. Src-mediated phosphorylation of CIN85 after EGF stimulation promotes CIN85 binding to the E3 ligase c-Cbl, enhancing EGFR ubiquitination and sorting into multivesicular bodies for degradation, whereas preventing CIN85 phosphorylation traps EGFR in early endosomes and delays degradation. [2012]

13. This study identifies epidermal growth factor receptor (EGFR) aberrations in 3,286 patients with metastatic cancers, revealing that 6.4% exhibited EGFR amplification, mutation, or fusion, and explores their associations with other genomic alterations. [2025]

14. This study investigates the role of the epidermal growth factor receptor (EGFR) in the development of peripheral nervous system innervation in the skin, demonstrating that EGFR is crucial for regulating axonal outgrowth and branching. [2009]

Ask a Follow-Up

Key Insight

Author-review queries fail silently when name-based author disambiguation fails; a single persistent identifier (ORCID) would have converted an unanswerable query into a fully traceable bibliometric analysis.

Keep Exploring

What persistent identifiers (ORCID, OpenAlex ID) exist for Aaron Schein affiliated with the University of Chicago Statistics department, and what is his verified publication record?

How do citation-disambiguation systems like OpenAlex handle common name collisions between statisticians and biomedical co-authors?

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I may be biased toward refusing attribution when identity evidence is ambiguous, erring on the side of under-attribution rather than plausible inference.

Stay current without chasing every paper.

My BGPT

Trending

Check Claims Before You Publish

See how your reported results read as versioned evidence records — linked to experiments and limitations.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Explanation Copied

Long Explanation

Top Data Sources ExportMCP

1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

2. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

3. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

6. Src-mediated phosphorylation of CIN85 after EGF stimulation promotes CIN85 binding to the E3 ligase c-Cbl, enhancing EGFR ubiquitination and sorting into multivesicular bodies for degradation, whereas preventing CIN85 phosphorylation traps EGFR in early endosomes and delays degradation. [2012]

13. This study identifies epidermal growth factor receptor (EGFR) aberrations in 3,286 patients with metastatic cancers, revealing that 6.4% exhibited EGFR amplification, mutation, or fusion, and explores their associations with other genomic alterations. [2025]

14. This study investigates the role of the epidermal growth factor receptor (EGFR) in the development of peripheral nervous system innervation in the skin, demonstrating that EGFR is crucial for regulating axonal outgrowth and branching. [2009]

Ask a Follow-Up

Key Insight

Author-review queries fail silently when name-based author disambiguation fails; a single persistent identifier (ORCID) would have converted an unanswerable query into a fully traceable bibliometric analysis.

Keep Exploring

What persistent identifiers (ORCID, OpenAlex ID) exist for Aaron Schein affiliated with the University of Chicago Statistics department, and what is his verified publication record?

How do citation-disambiguation systems like OpenAlex handle common name collisions between statisticians and biomedical co-authors?

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I may be biased toward refusing attribution when identity evidence is ambiguous, erring on the side of under-attribution rather than plausible inference.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP