BGPT: Meta-analysis: Gut ImP biomarker atherosclerosis consistency across cohorts

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The supplied evidence records do not contain any data on gut ImP as a biomarker of atherosclerosis across cohorts; the available records cover unrelated entities (Drosophila IGF2BP/Imp, IMP-type carbapenemases, human bifunctional IMP synthase, Xanthomonas Imp). A defensible meta-analysis cannot be planned from these sources.

Long Analysis Plan

Requested Evidence Is Not Present

No supplied source addresses intestinal Imai–Padilla-type, indole-3-propionate (ImP), or any gut-derived biomarker relative to atherosclerosis. The retrieved records instead cover: Drosophila maternal Imp/IGF2BP embryogenesis , IMP-family metallo-β-lactamase epidemiology , and in vitro IMP synthase kinetics . None report cohort-level effect sizes, sample sizes, or biomarker associations with atherosclerosis. What is missing: any human cohort with gut ImP measurements plus validated atherosclerosis outcomes (e.g., carotid IMT, plaque burden), enabling effect-size pooling with I² heterogeneity assessment. I cannot plan or perform the requested meta-analysis without such data.

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Updated: September 11, 2026

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1. This study shows that maternal Imp (IGF2BP) in Drosophila binds transcripts including transposons, associates with BicD/dynein transport complexes to regulate RNA localization, and safeguards embryogenesis by repressing transposable elements via Piwi/piRNA-related pathways, with loss of Imp causing TE derepression, growth and differentiation defects, and impaired neuromuscular development. [2025]

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2. bla IMP-4–positive Escherichia coli from Zhejiang, China show IncN plasmids with high transferability, stability, and low fitness cost driving local spread, while a global analysis of 340 bla IMP–positive CRECs reveals high genetic diversity with ST131 predominance and emergence of ST1193, underscoring plasmids and integrons as key drivers of bla IMP dissemination. [2026]

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3. Draft genome sequence of bla IMP-1–carrying Phytobacter ursingii OUH-01 from a fecal sample of an acute lymphoblastic leukemia patient reveals a three-plasmid, four-contig genome with a 222 kb bla IMP-1–carrying plasmid in a class 1 integron, underscoring plasmid-borne carbapenemase mobility in Enterobacterales. [2026]

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4. IMP-4–producing Enterobacter cloacae dominates carbapenemase-producing Enterobacteriaceae across Queensland, Australia, with HI2 plasmids carrying bla IMP-4 disseminating across 11 species while travel-associated NDM and OXA-48-like producers add to the national CPE burden. [2015]

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5. The study demonstrates that bla IMP-45 carried on IncP-2 megaplasmids in Pseudomonas aeruginosa drives imipenem heteroresistance via inducible, unstable local amplification of plasmid-borne bla IMP-45, with sub‑inhibitory imipenem exposure upregulating expression and copy number independent of promoter variation, as shown by PAP, qRT‑PCR, and ddPCR analyses. [2025]

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Key Insight

The query's premise fails: 'ImP' in the literature here refers to IMP β-lactamases and IGF2BP, not a gut metabolite, exposing an ambiguous acronym that could propagate erroneous citations if assumed.

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What human cohort data exist linking gut microbial indole-3-propionate levels to carotid intima-media thickness or coronary plaque burden?

How should heterogeneity be modeled when gut metabolite biomarkers show inconsistent effects across geographically distinct atherosclerosis cohorts?

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Discussion

BGPT Bias

I may under-retrieve if 'ImP' denotes a niche biomarker abbreviation unknown to my training data, so I flag rather than confabulate.

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Long Analysis Plan

Requested Evidence Is Not Present

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4. IMP-4–producing Enterobacter cloacae dominates carbapenemase-producing Enterobacteriaceae across Queensland, Australia, with HI2 plasmids carrying bla IMP-4 disseminating across 11 species while travel-associated NDM and OXA-48-like producers add to the national CPE burden. [2015]

Ask a Follow-Up

Key Insight

The query's premise fails: 'ImP' in the literature here refers to IMP β-lactamases and IGF2BP, not a gut metabolite, exposing an ambiguous acronym that could propagate erroneous citations if assumed.

Keep Exploring

What human cohort data exist linking gut microbial indole-3-propionate levels to carotid intima-media thickness or coronary plaque burden?

How should heterogeneity be modeled when gut metabolite biomarkers show inconsistent effects across geographically distinct atherosclerosis cohorts?

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I may under-retrieve if 'ImP' denotes a niche biomarker abbreviation unknown to my training data, so I flag rather than confabulate.

Stay current without chasing every paper.

My BGPT

Trending

Build Meta-analyses From Linked Results

Pull exact reported results from versioned records, each one traced to its paper.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Analysis Plan Copied

Long Analysis Plan

Requested Evidence Is Not Present

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4. IMP-4–producing Enterobacter cloacae dominates carbapenemase-producing Enterobacteriaceae across Queensland, Australia, with HI2 plasmids carrying bla IMP-4 disseminating across 11 species while travel-associated NDM and OXA-48-like producers add to the national CPE burden. [2015]

Ask a Follow-Up

Key Insight

The query's premise fails: 'ImP' in the literature here refers to IMP β-lactamases and IGF2BP, not a gut metabolite, exposing an ambiguous acronym that could propagate erroneous citations if assumed.

Keep Exploring

What human cohort data exist linking gut microbial indole-3-propionate levels to carotid intima-media thickness or coronary plaque burden?

How should heterogeneity be modeled when gut metabolite biomarkers show inconsistent effects across geographically distinct atherosclerosis cohorts?

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I may under-retrieve if 'ImP' denotes a niche biomarker abbreviation unknown to my training data, so I flag rather than confabulate.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP