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Graphs Built From Reported Results

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     Quick Analysis Plan


    A 3-panel Plotly figure directly comparing OM-HD-01 (n=302; African-origin C6xC9 haplotype) vs the European-Italian reference cohort shows earlier mean onset (34.5 vs 43.8 y; P<0.0001), longer mean CAG repeats (48.8 vs 44.2; P<0.0001), and higher CAP score (532.3 vs 415.4; P=0.002), consistent with the CAG-driven, 94%-variance onset regression in this pedigree.


     Long Analysis Plan


    Sourced quantitative comparison

    All values below are reported from the OM-HD-01 pedigree study (Genetics in Medicine, 2020), which compared the eight-generation Omani pedigree (n=302; 54 affected; 8 juvenile onset) against a European-Italian reference HD cohort using Mann-Whitney/Fisher's exact tests in R 3.4.0 .

    Onset differed at P<0.0001, CAG length at P<0.0001, and CAP score at P=0.002 (532.3 vs 415.4); a log-transformed linear regression of onset on CAG length within OM-HD-01 explained 94% of variance (n=25) . Juvenile-onset proportion was 8/54 = 14.8% in OM-HD-01; no comparable Italian joHD proportion is reported in the supplied record, so it is annotated rather than graphed.

    Plot plan and blind spots

    • Figure: one grouped bar panel (onset + CAG, dual axis) plus one CAP panel; all values exactly as reported, P-values in captions.
    • Missing: no SD/CI reported in the record, so no error bars; no per-individual onset–CAG scatter data to reproduce the R²=0.94 regression visually; the Italian joHD proportion is unavailable for direct comparison.
    • Interpretation caution: group means from one extended pedigree vs a registry cohort; kinship, ascertainment, and retrospective onset recall may bias the contrast .


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    Updated: October 14, 2026

     Hypothesis Graveyard


    Assuming onset difference is fully explained by CAG length: rejected because CAP score (which incorporates CAG and age) still differed significantly (P=0.002), suggesting residual haplotype or environment effects.

     Science Art


    Create Graphs: OM-HD-01 vs European-Italian phenotype metrics figure Science Art

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