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Traceable Claims in Immunology

Check what immune studies actually reported — results, scope, and sources you can verify.Know what the science actually supports before you trust the answer.

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     Quick Explanation


    I can’t accurately list “key fundamental scRNA-seq B cell lineage studies” from the **research dataset provided in your message**, because it contains **no B-cell scRNA-seq lineage papers** (only pulmonary fibrosis iPSC lung work, T-cell/Nef/HIV, prognostic CLL marker studies, etc.). If you want, I can pull the missing B-cell lineage scRNA-seq literature via BGPT and then produce the requested lineage maps + a curated “foundational paper” list with inline DOI citations.


     Long Explanation


    Status: missing required B-cell scRNA-seq source papers
    Your provided research items (DOIs like 10.64898/2026.01.30.702837, 10.1101/2025.10.03.680133, 10.1101/2025.08.13.669665, etc.) do not include studies that define B cell lineages using scRNA-seq. Because BGPT requires inline citations for every claim, I cannot safely construct a “key fundamental B-cell scRNA-seq lineage” bibliography without fetching the correct sources.
    What I can do immediately (once you allow source retrieval)
    I will:
    • Search BGPT for foundational scRNA-seq B cell lineage papers (human + mouse), then curate a paper-by-paper lineage evidence map.
    • Create a Plotly figure summarizing how each paper supports: naïve → germinal center (GC) → class-switched → memory/plasma (only where supported by citations).
    • Create a table of: species, tissue, sequencing chemistry, marker program, lineage inference method (e.g., pseudotime/trajectory), and key lineage conclusions.
    • Flag blind spots: sampling bias, dissociation bias, batch effects, doublets, marker ambiguity, and inference fragility.
    Why I’m not answering from the current dataset
    The items you provided include (examples):
    • 10.64898/2026.01.30.702837 — lung fibrosis co-culture with scRNA-seq (not B-cell lineages).
    • 10.1101/2025.10.03.680133 — Th2 progenitors (T cells), scRNA-seq + scTCR-seq.
    • 10.1101/2025.08.13.669665 — B-ALL immune killing with RNA profiling (not B-cell lineage scRNA-seq atlases).
    Without B-cell lineage scRNA-seq papers in the supplied sources, any “key studies” list would be either uncited (violating your rules) or fabricated.
    Next step
    Click the BGPT fetch button above, or run the AI scientist agent below to iteratively retrieve the right papers and then generate the lineage map + curated foundational study list.


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    Updated: March 24, 2026

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