BGPT: Create Tables: SSTI Types, Age, Malignancy distribution from paper (n=227)

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Quick Analysis Plan Copied

The supplied evidence records contain no data on skin and soft tissue infection (SSTI) types, age distribution, malignancy status, or any cohort of n=227; the largest clinical cohort available is n=200 advanced NSCLC patients , and no SSTI paper is present. Tables cannot be created without the source paper.

Long Analysis Plan

The requested tables cannot be built from the supplied evidence. None of the provided claim-level records describe a skin and soft tissue infection (SSTI) cohort, SSTI subtype classification, patient age strata, malignancy distribution, or any sample of n=227. The available records cover: (1) LDOC1/EGFR trafficking in NSCLC (n=200 tumor cohort) ; (2) SstI restriction enzyme lambda vectors; (3) EGFR copy-number screening in lung adenocarcinoma (n=96) ; (4) apoC3 SstI polymorphism and atherosclerosis (n=628) ; and (5) FUT8/EGFR antiviral immunity. "SstI" here refers to the restriction endonuclease from Streptomyces stanfordii, not SSTI (skin and soft tissue infection) — a likely keyword collision.

What is missing: the specific source paper with n=227 reporting SSTI types, age, and malignancy distribution. Please upload or link that paper (PDF or DOI); once supplied, the tables and distributions can be constructed directly.

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Updated: October 26, 2026

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1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

9QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

2. This study describes the construction of lambda vectors suitable for the restriction enzyme SstI from Streptomyces sanfordii, enabling the cloning of larger DNA fragments into E. coli. [1977]

7QualityResults Limitations Context Blindspots Methods Sample Data

↗ Paper Review ↗ Full Paper

3. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

4. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

7QualityResults Limitations Context Blindspots Methods Sample Data

↗ Paper Review ↗ Full Paper

5. A comprehensive review of EGFR pathway alterations in NSCLC, detailing activating EGFR mutations, copy-number changes, downstream signaling, predictive biomarkers for EGFR-targeted therapies, and mechanisms of resistance, with emphasis on the need for integrated molecular stratification for personalized treatment. [2011]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

Key Insight

The query likely conflated 'SstI' (a Streptomyces restriction enzyme appearing in several retrieved papers) with 'SSTI' (skin and soft tissue infection), producing off-topic evidence records — a classic keyword-collision retrieval failure.

Keep Exploring

Which SSTI subtypes (cellulitis, abscess, necrotizing fasciitis) dominate cohorts of immunocompromised or malignancy-associated patients?

What malignancy prevalence is typically reported in hospitalized SSTI cohorts, and how does it affect mortality outcomes?

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Discussion

BGPT Bias

As a retrieval-based system I cannot access papers not supplied in the evidence layer, so I must report the gap rather than fabricate an SSTI cohort table.

Stay current without chasing every paper.

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Tables Built From Reported Results

Compile exact reported values into tables, each cell traceable to a source paper.Know what the science actually supports before you trust the answer.

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Long Analysis Plan

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1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

2. This study describes the construction of lambda vectors suitable for the restriction enzyme SstI from Streptomyces sanfordii, enabling the cloning of larger DNA fragments into E. coli. [1977]

3. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

4. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

6. This study investigates the cleavage sites of the SstI endonuclease from Streptomyces stanfordii on the genomes of human adenoviruses types 2 and 5, revealing specific locations of restriction sites that may aid in the purification and cloning of DNA fragments containing leader sequences. [1979]

7. The study shows that the S2 allele of the SstI polymorphism in the apoC3 gene is associated with higher plasma apoCIII and unfavorable lipid profiles, contributing to increased atherosclerosis risk in the Li ethnic group of China, with distinct patterns compared to Han individuals. [2017]

9. Two common APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster show no significant association with incident myocardial infarction in middle-aged US men, though the X1-S2 haplotype is tied to higher triglyceride levels. [2004]

10. Src-mediated phosphorylation of CIN85 after EGF stimulation promotes CIN85 binding to the E3 ligase c-Cbl, enhancing EGFR ubiquitination and sorting into multivesicular bodies for degradation, whereas preventing CIN85 phosphorylation traps EGFR in early endosomes and delays degradation. [2012]

Ask a Follow-Up

Key Insight

The query likely conflated 'SstI' (a Streptomyces restriction enzyme appearing in several retrieved papers) with 'SSTI' (skin and soft tissue infection), producing off-topic evidence records — a classic keyword-collision retrieval failure.

Keep Exploring

Which SSTI subtypes (cellulitis, abscess, necrotizing fasciitis) dominate cohorts of immunocompromised or malignancy-associated patients?

What malignancy prevalence is typically reported in hospitalized SSTI cohorts, and how does it affect mortality outcomes?

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

As a retrieval-based system I cannot access papers not supplied in the evidence layer, so I must report the gap rather than fabricate an SSTI cohort table.

Stay current without chasing every paper.

My BGPT

Trending

Tables Built From Reported Results

Compile exact reported values into tables, each cell traceable to a source paper.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Analysis Plan Copied

Long Analysis Plan

Top Data Sources ExportMCP

1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

2. This study describes the construction of lambda vectors suitable for the restriction enzyme SstI from Streptomyces sanfordii, enabling the cloning of larger DNA fragments into E. coli. [1977]

3. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

4. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

6. This study investigates the cleavage sites of the SstI endonuclease from Streptomyces stanfordii on the genomes of human adenoviruses types 2 and 5, revealing specific locations of restriction sites that may aid in the purification and cloning of DNA fragments containing leader sequences. [1979]

7. The study shows that the S2 allele of the SstI polymorphism in the apoC3 gene is associated with higher plasma apoCIII and unfavorable lipid profiles, contributing to increased atherosclerosis risk in the Li ethnic group of China, with distinct patterns compared to Han individuals. [2017]

9. Two common APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster show no significant association with incident myocardial infarction in middle-aged US men, though the X1-S2 haplotype is tied to higher triglyceride levels. [2004]

10. Src-mediated phosphorylation of CIN85 after EGF stimulation promotes CIN85 binding to the E3 ligase c-Cbl, enhancing EGFR ubiquitination and sorting into multivesicular bodies for degradation, whereas preventing CIN85 phosphorylation traps EGFR in early endosomes and delays degradation. [2012]

Ask a Follow-Up

Key Insight

The query likely conflated 'SstI' (a Streptomyces restriction enzyme appearing in several retrieved papers) with 'SSTI' (skin and soft tissue infection), producing off-topic evidence records — a classic keyword-collision retrieval failure.

Keep Exploring

Which SSTI subtypes (cellulitis, abscess, necrotizing fasciitis) dominate cohorts of immunocompromised or malignancy-associated patients?

What malignancy prevalence is typically reported in hospitalized SSTI cohorts, and how does it affect mortality outcomes?

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

As a retrieval-based system I cannot access papers not supplied in the evidence layer, so I must report the gap rather than fabricate an SSTI cohort table.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP