BGPT: Best Evidence: Yukiko Hori Chemogenetic Primate Studies

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Quick Analysis Plan Copied

The supplied evidence cannot support this query: none of the provided records relate to Yukiko Hori, chemogenetics (DREADDs), or primate studies — all are EGFR trafficking and NSCLC papers.

Long Analysis Plan

Evidence mismatch. No record in the supplied corpus concerns Yukiko Hori, chemogenetic (DREADD-based) primate work, or a rigor audit of such studies. The records instead cover: LDOC1 control of EGFR internalization and gefitinib response in NSCLC , EGFR copy-number screening , pSTAT3-driven EGFR homeostasis, viral FUT8-EGFR fucosylation , CIN85 phosphorylation in EGFR sorting, and EGFR-TKI sensitivity profiling.

What is missing: to audit the Hori chemogenetic primate evidence, the actual primary papers (e.g., DREADD ligand kinetics, behavioral endpoints, n per group, blinding, and preregistration status) must be supplied; none are present, so no rigorous critique can be performed without confabulating claims.

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Updated: October 25, 2026

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1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

9QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

2. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

3. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

7QualityResults Limitations Context Blindspots Methods Sample Data

↗ Paper Review ↗ Full Paper

4. A comprehensive review of EGFR pathway alterations in NSCLC, detailing activating EGFR mutations, copy-number changes, downstream signaling, predictive biomarkers for EGFR-targeted therapies, and mechanisms of resistance, with emphasis on the need for integrated molecular stratification for personalized treatment. [2011]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

5. The study shows that hepatitis C virus (and other enveloped viruses) upregulates host FUT8 to increase EGFR core fucosylation, activating EGFR-JAK1-STAT3 signaling that recruits Trim40 to promote RIG-I degradation and suppresses type I interferon responses, with FUT8 inhibition or hepatic Fut8 silencing reducing RNA viral replication in vitro and in vivo, revealing a viral immune evasion mechanism and potential antiviral target. [2024]

9QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

Key Insight

A rigor audit cannot precede the evidence itself; here the premise supplied entirely unrelated NSCLC EGFR papers, so the honest scientific answer is to reject the premise rather than fabricate an audit.

Keep Exploring

What sample sizes and blinding standards are considered minimum for credible chemogenetic primate behavioral studies?

How do DREADD ligand off-target effects complicate interpretation of primate chemogenetics?

Hypothesis Graveyard

That 'Best Evidence: Yukiko Hori Chemogenetic Primate Studies' refers to the supplied NSCLC EGFR corpus — falsified by inspection: zero overlap in author, method, model organism, or field.

Potential Experiments

Re-run the query after attaching the Hori et al. primary primate DREADD papers, including sample sizes, behavioral assay protocols, and blinding statements, to enable a claim-level rigor audit.

Cross-check the Hori chemogenetic primate findings against independent replication attempts in marmoset or macaque DREADD studies to test reproducibility.

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I lean toward strict source-adherence, which risks under-delivering when a user's query and supplied corpus diverge, but fabricating an audit would be worse.

Stay current without chasing every paper.

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Review Papers Against Their Own Results

Check whether claims match experiments, exact reported results, and stated limitations.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Analysis Plan Copied

Long Analysis Plan

Top Data Sources Export MCP

1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

2. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

3. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

6. Src-mediated phosphorylation of CIN85 after EGF stimulation promotes CIN85 binding to the E3 ligase c-Cbl, enhancing EGFR ubiquitination and sorting into multivesicular bodies for degradation, whereas preventing CIN85 phosphorylation traps EGFR in early endosomes and delays degradation. [2012]

12. This narrative review argues that EGFR-mutated NSCLC has an immunosuppressive tumor microenvironment, low TMB, altered PD-L1/CD8/Treg/TAM features, and immunotherapy resistance, supporting combined TKI/immunotherapy and inflammation-targeting strategies. [2022]

Ask a Follow-Up

Key Insight

A rigor audit cannot precede the evidence itself; here the premise supplied entirely unrelated NSCLC EGFR papers, so the honest scientific answer is to reject the premise rather than fabricate an audit.

Keep Exploring

What sample sizes and blinding standards are considered minimum for credible chemogenetic primate behavioral studies?

How do DREADD ligand off-target effects complicate interpretation of primate chemogenetics?

Hypothesis Graveyard

That 'Best Evidence: Yukiko Hori Chemogenetic Primate Studies' refers to the supplied NSCLC EGFR corpus — falsified by inspection: zero overlap in author, method, model organism, or field.

Potential Experiments

Re-run the query after attaching the Hori et al. primary primate DREADD papers, including sample sizes, behavioral assay protocols, and blinding statements, to enable a claim-level rigor audit.

Cross-check the Hori chemogenetic primate findings against independent replication attempts in marmoset or macaque DREADD studies to test reproducibility.

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I lean toward strict source-adherence, which risks under-delivering when a user's query and supplied corpus diverge, but fabricating an audit would be worse.

Stay current without chasing every paper.

My BGPT

Trending

Review Papers Against Their Own Results

Check whether claims match experiments, exact reported results, and stated limitations.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Analysis Plan Copied

Long Analysis Plan

Top Data Sources ExportMCP

1. LDOC1 interacts with clathrin adaptors AP1M1 and AP2M1 to regulate EGFR internalization and recycling, modulating EGFR signaling and gefitinib response in EGFR-mutant NSCLC, with LDOC1 loss promoting RTK activation and gefitinib resistance while associating with poorer patient outcomes. [2024]

2. This study demonstrates that pSTAT3 transactivates EGFR to maintain EGFR protein homeostasis and contributes to resistance against EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells. [2024]

3. This study investigates the relationship between EGFR gene copy number alterations and EGFR mutation status in lung adenocarcinoma, concluding that EGFR gene copy number as detected by SISH is not a reliable screening tool for selecting patients for EGFR mutation testing. [2014]

6. Src-mediated phosphorylation of CIN85 after EGF stimulation promotes CIN85 binding to the E3 ligase c-Cbl, enhancing EGFR ubiquitination and sorting into multivesicular bodies for degradation, whereas preventing CIN85 phosphorylation traps EGFR in early endosomes and delays degradation. [2012]

12. This narrative review argues that EGFR-mutated NSCLC has an immunosuppressive tumor microenvironment, low TMB, altered PD-L1/CD8/Treg/TAM features, and immunotherapy resistance, supporting combined TKI/immunotherapy and inflammation-targeting strategies. [2022]

Ask a Follow-Up

Key Insight

A rigor audit cannot precede the evidence itself; here the premise supplied entirely unrelated NSCLC EGFR papers, so the honest scientific answer is to reject the premise rather than fabricate an audit.

Keep Exploring

What sample sizes and blinding standards are considered minimum for credible chemogenetic primate behavioral studies?

How do DREADD ligand off-target effects complicate interpretation of primate chemogenetics?

Hypothesis Graveyard

That 'Best Evidence: Yukiko Hori Chemogenetic Primate Studies' refers to the supplied NSCLC EGFR corpus — falsified by inspection: zero overlap in author, method, model organism, or field.

Potential Experiments

Re-run the query after attaching the Hori et al. primary primate DREADD papers, including sample sizes, behavioral assay protocols, and blinding statements, to enable a claim-level rigor audit.

Cross-check the Hori chemogenetic primate findings against independent replication attempts in marmoset or macaque DREADD studies to test reproducibility.

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

I lean toward strict source-adherence, which risks under-delivering when a user's query and supplied corpus diverge, but fabricating an audit would be worse.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP