BGPT: Best Evidence: Hongbing Fu : Collect Top Cited Papers (DOIs) Method Rigor Check

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The collection is internally coherent but the method shows a critical ambiguity: the search term "DOI" conflated the digital object identifier with the psychedelic drug 2,5-dimethoxy-4-iodoamphetamine and the enzyme substrate 2-deoxy-scyllo-inosose, so most retrieved papers are drug/biochemistry studies rather than identifier-related work, and no citation counts were supplied to verify a "top cited" ranking.

Long Analysis Plan

Method Rigor Check: Entity Ambiguity Is the Dominant Flaw

The collected records reveal a term disambiguation failure at the heart of the query. Of 8 retrieved papers, only one directly concerns digital object identifiers as a scholarly-infrastructure topic . The remaining seven were retrieved because the acronym DOI matches (a) the psychedelic 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane in rat discrimination, mouse vision, olfactory search, auditory cortex, and tic-like behavior studies ; and (b) 2-deoxy-scyllo-inosose (DOI synthase) in aminoglycoside biosynthesis ; plus (c) depth-of-interaction (DOI) in a handheld Compton camera . A "top cited papers by DOI" collection should not span neuropharmacology, gamma-ray detector engineering, enzymology, and probiotics.

Figure 1: Rubric scores from the supplied records (sourced metadata, not independent ratings). Two records (PS128 tics; auditory 2024) lack reproducibility scores, and the Scientometrics record lacks generality/usefulness/reproducibility scores — an inconsistency in extraction coverage.

Rigor Checklist Verdict

Citation counts: The "incoming_citations" field is empty for 7 of 8 records; only the V1 vision preprint lists one incoming citation. No ranking by citation count is verifiable from the supplied data — the "top cited" premise is unsupported.
Temporal spread: Records span 1986–2025, violating the citation half-life assumption of a current top-cited snapshot; a 1986 rat discrimination paper may accumulate citations over decades, biasing against recent high-impact preprints.
Extraction inconsistency: 6 of 8 records use a "legacy" schema without claim-level evidence units; only the PS128 record uses the structured evidence.v4 schema with falsification criteria and provenance hashes .
Methodological soundness of underlying sources: Mixed — several animal studies use small samples (n=4 mice , n=6 rats ), and hardware validation relies on a single lab-built detector .

What would change this verdict: supplying per-record citation counts, a stricter disambiguation query (e.g., "digital object identifier" OR author-constrained terms), and uniform evidence.v4 extraction would either validate or refute the "top cited" framing. If Hongbing Fu is an intended author constraint, none of the 8 records demonstrably match a single author, suggesting the author filter failed or was never applied.

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Updated: October 26, 2026

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1. In six male Sprague-Dawley rats trained to discriminate 0.5 mg/kg racemic DOI from saline, the DOI stimulus generalized to DOM but not to 8-OH-DPAT or TFMPP, was antagonized in a dose-dependent manner by ketanserin, and LSD cross-generalization was observed, supporting that the DOI discriminative stimulus is mediated by 5-HT2 receptor activation. [1986]

7QualityResults Limitations Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

2. This study investigates the effects of the psychedelic drug DOI on olfactory search behavior in mice, revealing that DOI decreases search accuracy, alters movement patterns, and increases sniff rates, indicating significant disruptions in olfactory processing. [2025]

8QualityResults Limitations Context Blindspots Methods Sample Conflict

↗ Paper Review ↗ Full Paper

3. This study shows that the serotonergic psychedelic DOI modulates active vision in freely moving mice by bidirectionally altering V1 neural responses during gaze shifts, with effects that are stimulus- and depth-specific, dependent on visual input, yet preserving the coarse-to-fine temporal organization of activity. [2025]

9QualityResults Limitations Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

4. Handheld Compton camera with depth-of-interaction capable Ce:GAGG scintillators and MPPC arrays achieves high angular resolution (~8° FWHM at 662 keV) and increased efficiency (1.5–2×) over non-DOI designs, enabling real-time 3-D gamma-ray hotspot imaging and field deployment in Fukushima. [2014]

8QualityResults Limitations Context Blindspots Methods Sample Data

↗ Paper Review ↗ Full Paper

5. In DOI-treated male Wistar rats, oral Lactobacillus plantarum PS128 reduced tic-like behaviors and PPI deficits at ≥10^9 CFU/day, modulated brain dopamine signaling, peripheral serotonin, and cecal microbiota. [2019]

7QualityResults Context Blindspots Methods Sample Conflict Data

↗ Paper Review ↗ Full Paper

Key Insight

The acronym "DOI" is a four-way homonym (digital object identifier, psychedelic drug, 2-deoxy-scyllo-inosose, depth-of-interaction), and keyword-based evidence retrieval silently blends all four literatures — a citation-collection pipeline that lacks acronym disambiguation can return topically incoherent "evidence" that looks rigorous because each individual record is well-scored.

Hypothesis Graveyard

Assumption that 'top cited' was verified: the records' incoming_citations fields are overwhelmingly empty, so no ranking was performed — the label was applied without the supporting metric, which is the defining rigor failure here.

Potential Experiments

Re-run the collection with explicit disambiguation: query each acronym sense separately ("digital object identifier" vs "2,5-dimethoxy-4-iodoamphetamine" vs "depth-of-interaction"), record citation counts for all results, and quantify the per-sense contamination rate of the original keyword search.

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Discussion

BGPT Bias

My critique privileges structured-claim schemas and disambiguation precision, potentially undervaluing that a broadened recall (even with collisions) can still surface high-quality individual records.

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Long Analysis Plan

Method Rigor Check: Entity Ambiguity Is the Dominant Flaw

Rigor Checklist Verdict

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2. This study investigates the effects of the psychedelic drug DOI on olfactory search behavior in mice, revealing that DOI decreases search accuracy, alters movement patterns, and increases sniff rates, indicating significant disruptions in olfactory processing. [2025]

5. In DOI-treated male Wistar rats, oral Lactobacillus plantarum PS128 reduced tic-like behaviors and PPI deficits at ≥10^9 CFU/day, modulated brain dopamine signaling, peripheral serotonin, and cecal microbiota. [2019]

7. This study assesses the availability of digital object identifiers (DOIs) in biomedical articles indexed in PubMed from 1966 to 2015, revealing a significant increase in DOI assignment over time and highlighting geographical disparities in DOI implementation among different countries. [2017]

8. This study investigates the effects of the serotonergic psychedelic DOI on auditory cortical neuron activity in awake mice, revealing that DOI increases neural response variability and impairs deviance detection without significantly altering frequency tuning. [2024]

11. This study investigates the effects of the psychedelic drug DOI on dopamine signaling in the nucleus accumbens during reward prediction tasks, revealing that DOI enhances dopamine release to predictable rewards and cues, potentially influencing learning mechanisms. [2024]

12. This study investigates the effects of the 5-HT 2A/2C receptor agonist DOI on micturition in chronic spinal cord injured rats, demonstrating that DOI enhances voiding efficiency by promoting external urethral sphincter burst activity. [2013]

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Key Insight

Hypothesis Graveyard

Assumption that 'top cited' was verified: the records' incoming_citations fields are overwhelmingly empty, so no ranking was performed — the label was applied without the supporting metric, which is the defining rigor failure here.

Potential Experiments

Re-run the collection with explicit disambiguation: query each acronym sense separately ("digital object identifier" vs "2,5-dimethoxy-4-iodoamphetamine" vs "depth-of-interaction"), record citation counts for all results, and quantify the per-sense contamination rate of the original keyword search.

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

My critique privileges structured-claim schemas and disambiguation precision, potentially undervaluing that a broadened recall (even with collisions) can still surface high-quality individual records.

Stay current without chasing every paper.

My BGPT

Trending

The Evidence Layer for Scientific AI

Ask questions across claims linked to experiments, exact results, limitations, and sources.Know what the science actually supports before you trust the answer.

Explore by Goal

Quick Analysis Plan Copied

Long Analysis Plan

Method Rigor Check: Entity Ambiguity Is the Dominant Flaw

Rigor Checklist Verdict

Top Data Sources ExportMCP

2. This study investigates the effects of the psychedelic drug DOI on olfactory search behavior in mice, revealing that DOI decreases search accuracy, alters movement patterns, and increases sniff rates, indicating significant disruptions in olfactory processing. [2025]

5. In DOI-treated male Wistar rats, oral Lactobacillus plantarum PS128 reduced tic-like behaviors and PPI deficits at ≥10^9 CFU/day, modulated brain dopamine signaling, peripheral serotonin, and cecal microbiota. [2019]

7. This study assesses the availability of digital object identifiers (DOIs) in biomedical articles indexed in PubMed from 1966 to 2015, revealing a significant increase in DOI assignment over time and highlighting geographical disparities in DOI implementation among different countries. [2017]

8. This study investigates the effects of the serotonergic psychedelic DOI on auditory cortical neuron activity in awake mice, revealing that DOI increases neural response variability and impairs deviance detection without significantly altering frequency tuning. [2024]

11. This study investigates the effects of the psychedelic drug DOI on dopamine signaling in the nucleus accumbens during reward prediction tasks, revealing that DOI enhances dopamine release to predictable rewards and cues, potentially influencing learning mechanisms. [2024]

12. This study investigates the effects of the 5-HT 2A/2C receptor agonist DOI on micturition in chronic spinal cord injured rats, demonstrating that DOI enhances voiding efficiency by promoting external urethral sphincter burst activity. [2013]

Ask a Follow-Up

Key Insight

Hypothesis Graveyard

Assumption that 'top cited' was verified: the records' incoming_citations fields are overwhelmingly empty, so no ranking was performed — the label was applied without the supporting metric, which is the defining rigor failure here.

Potential Experiments

Re-run the collection with explicit disambiguation: query each acronym sense separately ("digital object identifier" vs "2,5-dimethoxy-4-iodoamphetamine" vs "depth-of-interaction"), record citation counts for all results, and quantify the per-sense contamination rate of the original keyword search.

Science Art

Science Movie

Make a narrated HD Science movie for this answer ($32 per minute)

Discussion

BGPT Bias

My critique privileges structured-claim schemas and disambiguation precision, potentially undervaluing that a broadened recall (even with collisions) can still surface high-quality individual records.

Stay current without chasing every paper.

My BGPT

Trending

Top Data Sources Export MCP