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Cancer Biology

Evidence-qualified paper reviews · Updated September 11, 2026

Transient plasticity in oncogenic transformation

Transient Plasticity Window in Transformation

HRAS-G12V plus p53 disruption reprograms entire cell populations through a transient plasticity window in a 2026 preprint, but fibroblast reversion, untested interferon causality, and only two cell lines keep the lineage-barrier model provisional.

Review: Oncogenic Transformation via Transient Plasticity

CAF Autophagy in Prostate Cancer

ATG5-dependent autophagy in cancer-associated fibroblasts promotes prostate cancer growth and invasion in a 2023 Apoptosis study, but a five-patient cohort, off-target 3-MA use, and an unidentified secreted mediator weaken the causal chain.

Review: CAF Autophagy Promotes Prostate Tumor Traits

Author Profile: Katerina Gurova

A barcoding null result supports a population-wide, reversible plasticity model over rare-clone selection, and Gurova's career record (h-index 38, FACT-targeting chromatin drugs) is mature, though key interferon-barrier claims remain causally untested.

Author Review: Katerina Gurova

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