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     Quick Answer


    CAMK II targets include proteins involved in synaptic plasticity, such as CREB, SynGAP, and various ion channels, influencing learning and memory processes.


     Long Answer


    Overview of CAMK II Targets

    Calcium/calmodulin-dependent protein kinase II (CAMK II) is a critical enzyme in calcium signaling pathways, particularly in neurons. It plays a significant role in various cellular processes, including synaptic plasticity, learning, and memory. The targets of CAMK II include a variety of proteins that are involved in these processes.

    Key Targets of CAMK II

    • CREB (cAMP response element-binding protein): CAMK II phosphorylates CREB, which is essential for gene transcription related to long-term potentiation (LTP) and memory consolidation .
    • SynGAP: CAMK II phosphorylates SynGAP, a synaptic Ras-GTPase activating protein, which modulates synaptic signaling and plasticity .
    • Ion Channels: CAMK II phosphorylates various ion channels, including NMDA receptors (NR2B subunit), which enhances calcium influx and contributes to synaptic plasticity .
    • Other Substrates: Additional targets include proteins involved in synaptic transmission such as IQSEC2, RPL6, ANK3, STX1B, and KCNQ5, which are also phosphorylated by CAMK II .

    Conclusion

    CAMK II is a pivotal kinase that targets a variety of proteins involved in synaptic plasticity and memory processes. Its ability to phosphorylate key substrates like CREB and SynGAP highlights its essential role in neuronal signaling and function.



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    Updated: January 21, 2025

     Bioinformatics Wizard



    This code analyzes the phosphorylation sites of CAMK II substrates using mass spectrometry data to identify novel targets.



     Hypothesis Graveyard


    The hypothesis that CAMK II only targets a limited number of proteins is unlikely, as recent studies have identified numerous substrates across various pathways.

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