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Implications of Oestrogen Therapy in Postmenopausal Women

Oestrogen therapy is commonly prescribed to postmenopausal women to manage various symptoms and health risks associated with menopause. The implications of this therapy can be categorized into benefits and risks.

Benefits of Oestrogen Therapy

• Relief from Menopausal Symptoms: Oestrogen therapy effectively alleviates vasomotor symptoms such as hot flashes, which affect over 80% of menopausal women Oestrogen therapy for hot flashes.
• Prevention of Osteoporosis: Oestrogen plays a crucial role in maintaining bone density. Its therapy is associated with a reduced risk of osteoporosis and related fractures in postmenopausal women Oestrogen therapy and osteoporosis.
• Cardiovascular Protection: Emerging evidence suggests that oestrogen therapy may reduce the risk of cardiovascular disease (CVD) in women, although this is still a subject of debate .

Risks Associated with Oestrogen Therapy

• Increased Cancer Risk: One of the most significant concerns regarding oestrogen therapy is its association with an increased risk of endometrial and breast cancers. Unopposed oestrogen therapy has been linked to a higher incidence of endometrial cancer Oestrogen therapy and cancer risk.
• Cardiovascular Events: While oestrogen may offer some cardiovascular benefits, it can also increase the risk of thromboembolic events, particularly in women with other risk factors Oestrogen therapy and cardiovascular risks.
• Psychological Effects: Some women report mood changes, including depression and anxiety, during oestrogen therapy, which can complicate treatment Psychological effects of oestrogen therapy.

Conclusion

The decision to initiate oestrogen therapy in postmenopausal women should be individualized, weighing the benefits of symptom relief and potential health improvements against the risks of cancer and cardiovascular events. Ongoing research is essential to refine guidelines and ensure that women can make informed choices about their health.